Stability investigation of hyaluronic acid based nanoemulsion and its potential as transdermal carrier
نویسنده
چکیده
In this study, stability of hyaluronic acid (HA) based nanoemulsion was systematically investigated. Factors including zeta potential, pH, crosslinking agents and degree of substitution (DS) were considered to assess their roles in stability. Nanoemulsions prepared from HA-GMS with higher DS showed smaller droplet sizes. In the presence of Ca2+ as a crosslinker, size distribution was improved to be more uniform at the expense of size increases within a controllable range. The optimal amount of Ca2+ usage
منابع مشابه
Development of Nanoemulsion as Carrier for Transdermal Delivery of Valsartan
The aim of the present study was to develop potential nanoemulsion for transdermal delivery of valsartan. The o/w nanoemulsion was prepared by screening the excipients from the nanoemulsion region of pseudoternary phase diagram. The prepared nanoemulsions were subjected to different thermodynamic stability tests. The composition of optimized formulation was Triacetin (13.6%), Chemophore EL (23....
متن کاملPreparation, Characterization and Stability Study of Dutasteride Loaded Nanoemulsion for Treatment of Benign Prostatic Hypertrophy
Benign prostatic hyperplasia (BPH) is the most common condition in aging men, associated with lower urinary tract symptoms. It is caused due to the augmented levels of the androgen dihydrotestosterone. Dutasteride, a 5α-Reductase inhibitor has been recommended for the treatment of BPH upon oral administration. However, long term oral administration of dutasteride may cause sexual problem in man...
متن کاملEnhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel
The aim of the present study was to investigate the potential of nanoemulsion formulation for topical delivery of Clobetasol propionate (CP) using algal oil (containing omega-3 fatty acids) as the oil phase. CP has anti-inflammatory, immunomodulatory and antiproliferative activities. However, its clinical use is restricted to some extent due to its poor permeability across the skin. Algal oil w...
متن کاملEnhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel
The aim of the present study was to investigate the potential of nanoemulsion formulation for topical delivery of Clobetasol propionate (CP) using algal oil (containing omega-3 fatty acids) as the oil phase. CP has anti-inflammatory, immunomodulatory and antiproliferative activities. However, its clinical use is restricted to some extent due to its poor permeability across the skin. Algal oil w...
متن کاملFormulation of mefenamic acid loaded transfersomal gel by thin film hydration technique and hand shaking method
Objective(s): The aim of present study is to formulate mefenamic acid transdermal gel based on vesicular drug delivery approaches.Materials and Methods: For the preparation of mefenamic acid transdermal gel, transfersomes were selected as colloidal carriers. Transfersomes were prepared by hand shaking and thin film hydration techniques. The obtained transfersomes were characterized for vesicula...
متن کامل